Breast cancer is considered as a killer disease and it is known to be the top cause of cancer death among women. According to American cancer society, about 1.3 million new breast cancer cases are diagnosed on an annually basis which includes 465,000 deaths. In order to successfully tackle this devastating disease, we must encourage innovative scientists to study cancer at its most basic level. In other words, breast cancer research work should be conducted at its molecular level. Also, besides the governments, private organizations should provide flexible funding to scientists who will be conducting breast cancer research work. Proper funding of breast cancer research projects; can not only lead to better prevention strategies but it can also help towards earlier diagnostic techniques and new anticancer drugs and treatments.

A world renowned cancer researcher, named Lothar Hirneise has come to an understanding that cancer exist with stress. He is of the opinion that when the mind is under constant stress, the body then produces high levels of stress hormone called Cortisol. The immune system gets suppressed with high levels of Cortisol in the body. Also, a stressed mind will release out Adrenaline to an extent of depletion. People suffering from cancer are found to be having almost no adrenaline in their cells. In fact, cells of cancer patients are often overloaded with insulin and plenty of sugar. Another  leading German cancer researcher by the name of ‘Ryke-Geerd Hamer has gone through twenty thousand cancer patients and found a direct relationship between psycho-emotional conflict and cancer patients. This occurs between 1 to 3 years, prior to cancer diagnosis and cancer forming within the body. Cancer patients, who have experienced a psycho – emotional conflict shock, in the form of loss of a loved one etc, few years prior to their cancer urine, has experienced emotional pain and stress within themselves. Such a state of mind can have an adverse effect on the immune system of the person’s body.

Recently, researchers who are working towards breast cancer research project, have developed and successfully tested a breast cancer vaccine which is likely to treat women with treatment – resistant HER2 – positive breast cancer and thus be able to prevent cancer re – occurrence. Breast cancer researchers look forward to use HER2 DNA vaccines for cancer – free women, in order to prevent initial development of such tumours. At present, therapies such as trastuzumab and lapatimib are used towards treating breast cancer patients. However, it was lately noticed that a huge group of patients develop a resistance towards trastuzumab and lapatimib. HER2 receptors are known to promote a particularly aggressive type of tumour that affects about thirty percent of breast cancer patients.

The new breast cancer vaccine is produced by the body’s own cells. It delivers a cancer fighting gene into cells, which then produce immune system proteins and also tumor – destroying cells. According to the lead researcher Wei – Zen Wei, a professor of immunology and microbiology at the Karmanos Cancer Institute, the vaccine is made by using so – called naked DNA from genes that produces the HER2 receptor. This DNA is put along with an immune stimulant. The process involved in the making of the vaccine, is called as electroporation. In this process, pulses of electricity were used in order to inject the vaccine into the leg muscles in mice. The genes moved towards the cells, which then produced HER2 receptors that led to activation of antibodies and immune cells called Killer T cells. This vaccine is unique and much more research will be further required so that it can one day be applicable towards humans for treating breast cancer.

Breaf History of Hyperthermia
The healing effect of heat treatment was already mentioned in the advanced cultures of the old Egypt (2400 B.C.), but only the medical professionals of the Greek Antique used this therapeutic approach consistently, acknowledged it and called it over-warming (in Greek: Hyperthermia). “Give me the power to produce fever and I heal every illness”, said Parmenides, Greek physician, 540-480 B.C.

Hyperthermia in cancer treatment
Hyperthermia (also called thermal therapy or thermotherapy) is an acute condition which occurs when the body produces or absorbs more heat than it can dissipate. It is usually caused by prolonged exposure to high temperatures. The heat-regulating mechanisms of the body eventually become overwhelmed and unable to effectively deal with the heat, causing the body temperature to climb uncontrollably.

Hyperthermia can also be created artificially by drugs or medical devices. In these instances it may be used to treat cancer and other conditions. Cancer cells are more heat-sensitive than healthy cells and their structure reacts differently to overheating. In 1910 the possibility of overheating in order to increase the radiation effect on malicious tumors was described for the first time. This already well-known and applied method was rediscovered as so called “whole body hyperthermia” in the beginning of the 1960s. Since the 70s a number of studies were run to further investigate this therapy form.

Research has shown that high temperatures (up to 44°C) can damage and kill cancer cells, usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia may shrink tumors.

Hyperthermia is almost always used with other forms of cancer therapy, such as radiation therapy and chemotherapy. Hyperthermia may make some cancer cells more sensitive to radiation or harm other cancer cells that radiation cannot damage. When hyperthermia and radiation therapy are combined, they are often given within an hour of each other. Hyperthermia can also enhance the effects of certain anticancer drugs, which is mutually strengthened thereby and a healing more likely – the so-called synergistic effect of hyperthermia. It was found out that cytostatic drugs (chemotherapy substances) clearly act more aggressively at temperatures over 40° C than within the range of the normal body temperature.

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